Zhou Yujuan, Wang Xu, Liu Yingying, Gu Yulu, Gu Renjun, Zhang Geng, Lin Qing
Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, China.
Department of Physiology and Pathophysiology, Health Science Center, Peking University, Beijing, China.
Front Neurosci. 2023 Feb 15;17:1125376. doi: 10.3389/fnins.2023.1125376. eCollection 2023.
Alzheimer's disease (AD) is a degenerative disease of the central nervous system, the most common type of dementia in old age, which causes progressive loss of cognitive functions such as thoughts, memory, reasoning, behavioral abilities and social skills, affecting the daily life of patients. The dentate gyrus of the hippocampus is a key area for learning and memory functions, and an important site of adult hippocampal neurogenesis (AHN) in normal mammals. AHN mainly consists of the proliferation, differentiation, survival and maturation of newborn neurons and occurs throughout adulthood, but the level of AHN decreases with age. In AD, the AHN will be affected to different degrees at different times, and its exact molecular mechanisms are increasingly elucidated. In this review, we summarize the changes of AHN in AD and its alteration mechanism, which will help lay the foundation for further research on the pathogenesis and diagnostic and therapeutic approaches of AD.
阿尔茨海默病（AD）是一种中枢神经系统退行性疾病，是老年期最常见的痴呆类型，它会导致思维、记忆、推理、行为能力和社交技能等认知功能逐渐丧失，影响患者的日常生活。海马体的齿状回是学习和记忆功能的关键区域，也是正常哺乳动物成年海马神经发生（AHN）的重要部位。AHN主要包括新生神经元的增殖、分化、存活和成熟，贯穿成年期，但AHN水平会随着年龄增长而下降。在AD中，AHN在不同时期会受到不同程度的影响，其确切分子机制也日益明晰。在本综述中，我们总结了AD中AHN的变化及其改变机制，这将有助于为进一步研究AD的发病机制以及诊断和治疗方法奠定基础。
