Kawamura S, Yasui N, Shirasawa M, Fukasawa H
Department of Surgical Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan.
Surg Neurol. 1990 Aug;34(2):101-6. doi: 10.1016/0090-3019(90)90104-w.
The effects of hyperbaric oxygenation on acute focal cerebral ischemia in rats were investigated. All rats suffered 4-hour middle cerebral artery occlusion. Nontreated controls had a 27.9% +/- 5.5% infarct volume, and a left/right hemispheric volume ratio of 109% +/- 3%. Animals treated between 2.5 and 3.5 hours following occlusion had an 18.1% +/- 9.7% infarct volume (p less than 0.01), and a 105% +/- 3% left/right hemispheric volume ratio (p less than 0.001). In conclusion, at least until 4 hours following an ischemic insult, hyperbaric oxygenation reduces ischemic neuronal injury and brain edema following middle cerebral artery occlusion in rats treated between 2.5 and 3.5 hours following occlusion.
研究了高压氧对大鼠急性局灶性脑缺血的影响。所有大鼠均经历了4小时的大脑中动脉闭塞。未经治疗的对照组梗死体积为27.9%±5.5%，左右半球体积比为109%±3%。在闭塞后2.5至3.5小时接受治疗的动物梗死体积为18.1%±9.7%（p<0.01），左右半球体积比为105%±3%（p<0.001）。总之，至少在缺血性损伤后4小时内，高压氧可减轻闭塞后2.5至3.5小时接受治疗的大鼠大脑中动脉闭塞后的缺血性神经元损伤和脑水肿。
