[高压氧抑制大鼠中性粒细胞浸润并减轻缺血后脑损伤]
[Hyperbaric oxygen inhibits neutrophil infiltration and reduces postischemic brain injury in rats].
作者信息
Atochin D N, Fisher D, Thom S R, Demchenko I T
机构信息
M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., Russia, 194223, St. Petersburg, pr. M. Toreza, 44.
出版信息
Ross Fiziol Zh Im I M Sechenova. 2001 Aug;87(8):1118-25.
PMID:11601155
Abstract
Reversible occlusion of the middle cerebral artery (MCA) was used to test hypothesis that hyperbaric oxygen inhibits the neutrophile infiltration into the ischemic brain thus reducing the brain injury. Treatment with hyperbaric oxygen prior to ischemia or during MCA occlusion significantly reduced neutrophile infiltration, motor disorders, and cerebral infarction volume.
摘要
大脑中动脉（MCA）可逆性闭塞被用于检验高压氧抑制中性粒细胞浸润至缺血性脑从而减轻脑损伤这一假说。在缺血前或MCA闭塞期间进行高压氧治疗可显著减少中性粒细胞浸润、运动障碍及脑梗死体积。
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