Fenton Flavio H, Gizzi Alessio, Cherubini Christian, Pomella Nicola, Filippi Simonetta
School of Physics, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Apr;87(4):042717. doi: 10.1103/PhysRevE.87.042717. Epub 2013 Apr 22.
Thermal effects affecting spatiotemporal behavior of cardiac tissue are discussed by relating temperature variations to proarrhythmic dynamics in the heart. By introducing a thermoelectric coupling in a minimal model of cardiac tissue, we are able to reproduce experimentally measured dynamics obtained simultaneously from epicardial and endocardial canine right ventricles at different temperatures. A quantitative description of emergent proarrhythmic properties of restitution, conduction velocity, and alternans regimes as a function of temperature is presented. Complex discordant alternans patterns that enhance tissue dispersion consisting of one wave front and three wave backs are described in both simulations and experiments. Possible implications for model generalization are finally discussed.
通过将温度变化与心脏中的促心律失常动力学联系起来，讨论了影响心脏组织时空行为的热效应。通过在心脏组织的最小模型中引入热电耦合，我们能够重现从不同温度下的犬心外膜和心内膜右心室同时获得的实验测量动力学。给出了作为温度函数的恢复、传导速度和交替变化等新兴促心律失常特性的定量描述。在模拟和实验中都描述了由一个波前和三个波后组成的增强组织离散度的复杂不协调交替变化模式。最后讨论了模型推广的可能影响。
