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[免疫吸附疗法治疗支气管哮喘患者。5年观察的后期结果]

[Immunosorption in the treatment of bronchial asthma patients. The late results of a 5-year observation].

作者信息

Chuchalin A G, Raudla L A

出版信息

Ter Arkh. 1990;62(3):78-82.

PMID:2368004
Abstract

Analysis was made of the long-term results of immunosorption in 30 patients afflicted with bronchial asthma. 26 patients (14 with hypersensitivity to home dust allergen and 12 with pollenosis associated with hypersensitivity to timothy pollen allergen) received extracorporeal immunosorption: 1 patient underwent extracorporeal lymphocytic perfusion, 3 patients extracorporeal anti-IgE-plasma immunosorption. The use of immunosorption provides short-term beneficial results. The follow-up for 1 to 5 years revealed that the procedure exerted a beneficial action in 24 patients. In 6 patients, immunosorption did not produce any noticeable effect or else it was short-lived. External respiratory function differed substantially before and after immunosorption and correlated with the clinical improvement of the patients' status. Examination of cellular humoral immunity permitted the positive dynamics to be established in the content of T-lymphocyte subpopulations, the total and specific IgE.

摘要

对30例支气管哮喘患者进行免疫吸附的长期结果进行了分析。26例患者(14例对屋尘过敏原过敏,12例对梯牧草花粉过敏原过敏伴花粉症)接受了体外免疫吸附:1例患者接受了体外淋巴细胞灌注,3例患者接受了体外抗IgE血浆免疫吸附。免疫吸附的应用产生了短期有益效果。1至5年的随访显示,该治疗方法对24例患者产生了有益作用。6例患者中,免疫吸附未产生任何明显效果,或者效果短暂。免疫吸附前后的肺通气功能有显著差异,且与患者病情的临床改善相关。对细胞体液免疫的检查发现,T淋巴细胞亚群、总IgE和特异性IgE的含量呈正向动态变化。

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