Landyshev Iu S, Grigorenko A A, Orlova E V
Ter Arkh. 1990;62(3):84-90.
Altogether 275 patients with bronchial asthma (BA) were examined for hypothalamo-pituitary-thyroid function by means of clinico-radionuclide and histomorphological studies with measurements in blood of thyrotropin, triiodothyronine, thyroxine, thyroxine-binding globulin, thyroxine efficacy ratio and cholesterol as well as of 131I absorption by the thyroid. Thyroid function was established to undergo biphasic changes. In patients with mild BA, thyroid function was activated in the paroxysmal period. Provided the disease progressed, the thyroid developed hypofunction, which was confirmed by the histomorphological findings. The rifothyronine test enabled one to establish that patients with grave BA given prednisolone and dexamethasone for a long time developed primary and secondary hypothyrosis, respectively.
对275例支气管哮喘（BA）患者进行了下丘脑-垂体-甲状腺功能检查，采用临床放射性核素和组织形态学研究方法，检测血液中的促甲状腺激素、三碘甲状腺原氨酸、甲状腺素、甲状腺素结合球蛋白、甲状腺素效能比和胆固醇，以及甲状腺对131I的摄取。结果发现甲状腺功能呈双相变化。在轻度BA患者中，发作期甲状腺功能被激活。随着病情进展，甲状腺出现功能减退，组织形态学检查结果证实了这一点。利福噻吨试验表明，长期使用泼尼松龙和地塞米松的重度BA患者分别出现原发性和继发性甲状腺功能减退。
