Földes J, Váradi G, Lakatos P, Bános C, Tarján G
Orv Hetil. 1989 Nov 5;130(45):2415-8.
The aim of the present study was to find out whether a change in the function of the pituitary-thyroid axis can be revealed in a relatively homogenous group of hematological patients. To clarify this problem serum levels of total-thyroxine and triidothyronine, free-thyroxine and free-triiodothyronine, reverse-triidothyronine and thyrotropin were detected in these patients. The majority of subjects with chronic myelogenous leukemia (in the remission phase) have normal pituitary-thyroid function, however a change in the peripheral metabolism of thyroxine can be revealed. Longitudinal studies in patients with acute myelogenous leukemia indicate that in some cases with the progression of the disease serum TSH and thyroid hormone levels decrease referring to secondary hypothyroidism and in these cases the measurement of serum free-thyroxine content by an analogue tracer method is not recommended. On the basis of the investigational results it is stated that in hematological patients the pituitary-thyroid function is influenced by the phase of illness and by the results of the given treatment.
本研究的目的是弄清楚在一组相对同质的血液病患者中，垂体 - 甲状腺轴功能的变化是否能够被揭示。为了阐明这个问题，检测了这些患者血清中的总甲状腺素、三碘甲状腺原氨酸、游离甲状腺素、游离三碘甲状腺原氨酸、反三碘甲状腺原氨酸和促甲状腺激素水平。大多数慢性粒细胞白血病（缓解期）患者的垂体 - 甲状腺功能正常，然而，可以揭示甲状腺素外周代谢的变化。对急性粒细胞白血病患者的纵向研究表明，在某些疾病进展的病例中，血清促甲状腺激素和甲状腺激素水平下降，提示继发性甲状腺功能减退，在这些病例中，不建议采用类似示踪剂法测定血清游离甲状腺素含量。根据研究结果表明，在血液病患者中，垂体 - 甲状腺功能受疾病阶段和特定治疗结果的影响。
