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支气管哮喘患者死因分析(基于13年前瞻性观察数据)

[An analysis of the causes of death in bronchial asthma patients (based on the data from a 13-year prospective observation)].

作者信息

Ivashkin V T, Sinopal'nikov A I, Sementsov P N, Alekseev V G, Klochkov O I

出版信息

Ter Arkh. 1990;62(3):90-5.

PMID:2368007
Abstract

The results of the catamnestic study of case reports and records of postmortem examination of 102 patients with bronchial asthma (BA) aged 47 to 88 years who died at a general hospital during 1976-1988 indicate that in the overwhelming majority of cases, there took place death "with asthma" rather than death "from asthma". At the same time the dominant pathology was coronary heart disease (acute coronary failure, myocardial infarction, progressive heart failure associated with atherosclerotic and postinfarction cardiosclerosis). Emphasis is laid on the fact that according to the autopsy data, the rate of the recognized stenosing atherosclerosis of the coronary arteries considerably exceeded the number of cases of coronary heart disease documented clinically (typical angina pectoris of effort, significant macrofocal myocardial infarction). The characteristic features of the group under observation included an unexpectedly frequent combination of BA and malignant neoplasms (24 cases), including lung cancer in 13 of these cases.

摘要

对1976 - 1988年间在一家综合医院死亡的102例年龄在47至88岁的支气管哮喘(BA)患者的病例报告和尸检记录进行的随访研究结果表明,在绝大多数情况下,死亡是“因哮喘发作”而非“死于哮喘”。与此同时,主要病理状况是冠状动脉疾病(急性冠状动脉衰竭、心肌梗死、与动脉粥样硬化和心肌梗死后心脏硬化相关的进行性心力衰竭)。需要强调的是,根据尸检数据,已确认的冠状动脉狭窄性动脉粥样硬化发生率大大超过临床记录的冠心病病例数(典型的劳力性心绞痛、明显的大灶性心肌梗死)。所观察的这组患者的特征包括BA与恶性肿瘤意外频繁合并(24例),其中13例为肺癌。

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