Marinin V F, Andriukin A A, Kuznetsov V P, Nastiukova E G, Dudkina L N, Niaĭkina N Iu, Beliaev D L
Ter Arkh. 1990;62(3):95-7.
The authors provide the results of the treatment with leukinferon for injections of 25 patients with steroid-dependent bronchial asthma. It is the authors' belief that leukinferon for injections may be recommended for introduction into multimodality schedules of the treatment of patients with the above-indicated pathology. The drug is tolerated well, without any phenomena of sensitization, when administered by inhalation in the form of aqueous aerosol in a dose of 10,000 IU/day. As a result of 6 to 8 injections, immunoreactivity showed a positive time-course of changes, the patients' clinical status improved, and the maintenance doses of glucocorticosteroids could be noticeably reduced.
作者提供了对25例类固醇依赖型支气管哮喘患者注射白细胞干扰素的治疗结果。作者认为，注射用白细胞干扰素可推荐用于上述病理状况患者的多模式治疗方案。当以10000 IU/天的剂量以水性气雾剂形式吸入给药时，该药物耐受性良好，无任何致敏现象。经过6至8次注射后，免疫反应性呈现出积极的时间变化过程，患者的临床状况得到改善，糖皮质激素的维持剂量可显著降低。
