用人脐带间充质干细胞衍生的外泌体再生损伤的肾脏。
Regenerating the injured kidney with human umbilical cord mesenchymal stem cell-derived exosomes.
作者信息
Dorronsoro Akaitz, Robbins Paul D
出版信息
Stem Cell Res Ther. 2013 Apr 25;4(2):39. doi: 10.1186/scrt187.
Abstract
Transplantation of adult stem cells is being used to facilitate repair or regeneration of damaged or diseased tissues. However, in many cases, the therapeutic effects of the injected stem cells are mediated by factors secreted by stem cells and not by differentiation of the transplanted stem cells. Recent reports have identified a class of microvesicles, termed exosomes, released by stem cells that are able to confer therapeutic effects on injured renal and cardiac tissue. In this issue of Stem Cell Research & Therapy, Zhou and colleagues demonstrate the ability of exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs), but not non-stem cell-derived exosomes, to improve acute kidney injury induced by cisplatin in rats. The authors demonstrate that hucMSC exosomes can reduce cisplatin-mediated renal oxidative stress and apoptosis in vivo and increase renal epithelial cell proliferation in culture. These results suggest that stem cell-derived exosomes, which are easy to isolate and safer to use than the parental stem cells, could have significant clinical utility.
摘要
成体干细胞移植正被用于促进受损或患病组织的修复或再生。然而，在许多情况下，注射的干细胞的治疗效果是由干细胞分泌的因子介导的，而不是由移植的干细胞分化介导的。最近的报告已经鉴定出一类由干细胞释放的微泡，称为外泌体，它们能够对受损的肾脏和心脏组织产生治疗作用。在本期《干细胞研究与治疗》中，周及其同事证明了源自人脐带间充质干细胞（hucMSC）的外泌体，而非非干细胞来源的外泌体，能够改善顺铂诱导的大鼠急性肾损伤。作者证明hucMSC外泌体可以在体内减轻顺铂介导的肾脏氧化应激和细胞凋亡，并在培养中增加肾上皮细胞增殖。这些结果表明，与亲代干细胞相比，干细胞来源的外泌体易于分离且使用更安全，可能具有显著的临床应用价值。
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