Faulhaber Gustavo Adolpho Moreira, Ascoli Bruna Maria, Lubini Adriano, Mossmann Márcio, Rossi Gabriela, Geib Guilherme, Furlanetto Tânia Weber
Postgraduate Program in Medicine, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil.
Rev Assoc Med Bras (1992). 2013 May-Jun;59(3):276-9. doi: 10.1016/j.ramb.2012.12.007. Epub 2013 May 13.
The aim of this study was to evaluate the association of serum magnesium levels with proton pump inhibitors (PPIs) use and other factors.
This was a cross-sectional study of 151 patients admitted with acute diseases in the Internal Medicine Division of the Hospital de Clinicas de Porto Alegre, after the exclusion of conditions that are commonly associated with hypomagnesemia: diarrhea; vomiting; chronic alcohol use; severely uncompensated diabetes mellitus; and chronic use of laxatives, diuretics or other drugs causing magnesium deficiency.
All patients had normal serum magnesium levels. Serum albumin and creatinine levels were positively associated with serum magnesium levels, after adjusting for confounders. There was no difference between mean serum magnesium levels of PPI users and non-users, nor between men and women; there was also no correlation among age, serum phosphorus, and potassium levels with serum magnesium levels. Limitations of this study include the absence of an instrument for measuring adherence to PPI use and the sample size.
The association of PPI use and hypomagnesemia is uncommon. Congenital defects in the metabolism of magnesium may be responsible for hypomagnesemia in some patients using this drug class.
本研究旨在评估血清镁水平与质子泵抑制剂（PPI）使用及其他因素之间的关联。
这是一项横断面研究，对阿雷格里港临床医院内科收治的151例急性病患者进行研究，排除了通常与低镁血症相关的情况：腹泻；呕吐；长期酗酒；严重失代偿性糖尿病；长期使用泻药、利尿剂或其他导致镁缺乏的药物。
所有患者血清镁水平均正常。校正混杂因素后，血清白蛋白和肌酐水平与血清镁水平呈正相关。PPI使用者和非使用者的平均血清镁水平之间没有差异，男性和女性之间也没有差异；年龄、血清磷和钾水平与血清镁水平之间也没有相关性。本研究的局限性包括缺乏测量PPI使用依从性的工具和样本量。
使用PPI与低镁血症之间的关联并不常见。镁代谢的先天性缺陷可能是某些使用此类药物的患者发生低镁血症的原因。
