Aydin M, Akkoyunlu M E, Yakar F, Ergul N, Sezer M
Department of Nuclear Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Department of Chest Diseases, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Rev Esp Med Nucl Imagen Mol. 2014 Jan-Feb;33(1):32-5. doi: 10.1016/j.remn.2013.03.003. Epub 2013 May 14.
Wegener's granulomatosis (WG) is an uncommon systemic vasculitis, which involves the upper and lower respiratory tracts and the kidneys. Because the patients generally present with clinical manifestations that are similar to common diseases, WG may be initially misdiagnosed as infection or malignancy. We report the case of a 55-year-old male presenting with weight loss, cough, hemoptysis, low-grade fever, and pulmonary nodules detected on the thoracic CT scan. Malignancy was initially suspected, so a PET/CT was performed. It demonstrated intense FDG uptake in the upper and lower respiratory system. The diagnosis of WG was based on PET findings, elevated serum levels of inflammatory markers, and the presence of c-ANCA. We consider that the knowledge of FDG-PET/CT findings may help to make an easier and earlier diagnosis of WG.
韦格纳肉芽肿（WG）是一种罕见的系统性血管炎，累及上、下呼吸道及肾脏。由于患者通常表现出与常见疾病相似的临床表现，WG最初可能被误诊为感染或恶性肿瘤。我们报告一例55岁男性患者，出现体重减轻、咳嗽、咯血、低热及胸部CT扫描发现肺部结节。最初怀疑为恶性肿瘤，因此进行了PET/CT检查。结果显示上、下呼吸系统有强烈的FDG摄取。WG的诊断基于PET检查结果、炎症标志物血清水平升高及c-ANCA的存在。我们认为，了解FDG-PET/CT检查结果可能有助于更轻松、更早地诊断WG。
