De Geeter Frank, Gykiere Pieterjan
Department of Nuclear Medicine, Algemeen Ziekenhuis Sint-Jan Brugge-Oostende Ruddershove 10, B-8000 Brugge, Belgium.
Hell J Nucl Med. 2016 Jan-Apr;19(1):53-6. doi: 10.1967/s002449910339. Epub 2016 Mar 1.
Granulomatosis with polyangiitis (GPA), formerly called Wegener's syndrome, is a vasculitis associated with antineutrophil cytoplasmic antibody and may occur in all ages but mostly in order adults. The organs most frequently involved are the ear, nose and throat (rhinitis, sinusitus, oral ulcers, chondritis), the lungs (nodules, sometimes cavitating, infiltrates, hilar adenopathy) and the kidneys (glomerulonephritis). As patients typically present with constitutional symptoms, the diagnosis can be challenging. We report the findings on position emission tomography/computed tomography (PET/CT) with fluorine-18-fluorodeoxyglucose ((18)F-FDG) in a patient with a limited form of GPA.
None of the findings on PET are specific for GPA, but in a given clinical context, they may contribute to early diagnosis. They may guide biopsy taking, and may determine the extent of the disease. During and after treatment, PET can be used to monitor disease activity.
肉芽肿性多血管炎（GPA），以前称为韦格纳肉芽肿，是一种与抗中性粒细胞胞浆抗体相关的血管炎，可发生于各年龄段，但多见于成年人。最常受累的器官是耳、鼻、喉（鼻炎、鼻窦炎、口腔溃疡、软骨炎）、肺（结节，有时有空洞形成、浸润、肺门淋巴结肿大）和肾脏（肾小球肾炎）。由于患者通常表现为全身症状，诊断可能具有挑战性。我们报告了1例局限性GPA患者的18F-氟脱氧葡萄糖（18F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）检查结果。
PET检查结果均非GPA所特有，但在特定临床背景下，它们可能有助于早期诊断。它们可指导活检取材，并可确定疾病范围。在治疗期间及治疗后，PET可用于监测疾病活动。
