Biomolecular NMR Spectroscopy, Leibniz Institute for Age Research-Fritz Lipmann Institute, Beutenbergstr. 11, 07745 Jena, Germany.
Bioinformatics. 2013 Jul 15;29(14):1750-7. doi: 10.1093/bioinformatics/btt278. Epub 2013 May 15.
Circular dichroism (CD) spectroscopy is one of the most versatile tools to study protein folding and to validate the proper fold of purified proteins. Here, we aim to provide a readily accessible, user-friendly and platform-independent tool capable of analysing multiple CD datasets of virtually any format and returning results as high-quality graphical output to the user.
CAPITO (CD Anaylsis and Plotting Tool) is a novel web server-based tool for analysing and plotting CD data. It allows reliable estimation of secondary structure content utilizing different approaches. CAPITO accepts multiple CD datasets and, hence, is well suited for a wide application range such as the analysis of temperature or pH-dependent (un)folding and the comparison of mutants.
http://capito.nmr.fli-leibniz.de.
cwiede@fli-leibniz.de or mago@fli-leibniz.de
Supplementary data are available at Bioinformatics online.
圆二色性（CD）光谱是研究蛋白质折叠和验证纯化蛋白质正确折叠的最通用工具之一。在这里，我们旨在提供一个易于访问、用户友好且与平台无关的工具，能够分析几乎任何格式的多个 CD 数据集，并将结果作为高质量的图形输出返回给用户。
CAPITO（CD 分析和绘图工具）是一种新型的基于网络服务器的工具，用于分析和绘制 CD 数据。它允许利用不同的方法可靠地估计二级结构含量。CAPITO 接受多个 CD 数据集，因此非常适合广泛的应用范围，例如分析温度或 pH 依赖性（解）折叠以及突变体的比较。
http://capito.nmr.fli-leibniz.de。
cwiede@fli-leibniz.de 或 mago@fli-leibniz.de
补充数据可在Bioinformatics 在线获得。
