Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
J Chin Med Assoc. 2013 May;76(5):296-8. doi: 10.1016/j.jcma.2013.01.003. Epub 2013 Mar 17.
Erythromelalgia is characterized by intense burning pain, erythema, and heat in affected areas after precipitating factors such as warm temperature or stress. It is refractory to treatment in some situations. We describe a woman with adenosquamous cell carcinoma of the lung and medically refractory erythromelalgia. The symptoms of erythromelalgia presented as refractory to any medical treatment. Due to the unresponsive nature of her condition, botulinum toxin type A (onabotulinumtoxin A) was injected over both of her cheeks, periodically for six cycles. Her symptoms responded dramatically to subcutaneous and intradermal injection of botulinum toxin type A. Repetitive injection demonstrated consistent and reproducible responses, and the efficacy was maintained for approximately 1 month. No adverse effects or complications were noted. Botulinum toxin type A might be safe and effective as an alternative treatment for refractory erythromelalgia, but further large-scale studies are required.
红斑性肢痛症的特征是在温暖的温度或压力等诱发因素后，受影响区域出现剧烈的灼烧痛、红斑和发热。在某些情况下，该病的治疗效果不佳。我们描述了一位患有肺腺鳞癌并伴有药物难治性红斑性肢痛症的女性。红斑性肢痛症的症状对任何药物治疗均无反应。由于她的病情没有反应，因此在她的两颊周期性地分 6 个周期注射了肉毒毒素 A（onabotulinumtoxin A）。她的症状对肉毒毒素 A 的皮下和皮内注射反应明显。重复注射显示出一致且可重复的反应，疗效维持约 1 个月。未观察到不良反应或并发症。肉毒毒素 A 可能是治疗难治性红斑性肢痛症的一种安全有效的替代治疗方法，但需要进一步的大规模研究。
