Department of Medicine, College of Physicians & Surgeons of Columbia University, 630 W 168th Str., New York, NY 10032, USA.
FEBS Lett. 2013 Jun 27;587(13):1911-4. doi: 10.1016/j.febslet.2013.05.007. Epub 2013 May 16.
The intercalated cell of the collecting tubule of the mammalian kidney is specialized for the transport of H(+) and HCO3. They exist in two forms; one specialized for acid secretion and the other secretes HCO3 into the urine. We discovered many years ago that feeding animals an acid diet converts the HCO3 secreting form to an acid secreting type. Here I discuss the molecular basis of this transformation. The conversion of the cell types is mediated by an extracellular matrix protein hensin (also known as DMBT1). However much remains to be identified in the differentiation of these cells.
哺乳动物肾脏集合管的闰细胞专门用于 H(+)和 HCO3 的转运。它们有两种形式存在，一种专门用于分泌酸，另一种则将 HCO3 分泌到尿液中。我们很多年前就发现，给动物喂食酸性饮食会将 HCO3 分泌形式转化为酸分泌类型。在这里，我讨论这种转化的分子基础。细胞类型的转换是由细胞外基质蛋白 hensin（也称为 DMBT1）介导的。然而，在这些细胞的分化过程中，还有很多问题需要确定。
