Lutze G, Schraermeyer T, Töpfer G, Urbahn H
Institut für Klinische Chemie und Laboratoriumsdiagnostik, Medinischen Akademie Magdeburg.
Z Med Lab Diagn. 1990;31(3):169-75.
The thrombin time is essential to control the fibrinolytic therapy with streptokinase. But it is not efficient to use the thrombin time to estimate the fibrinolytic activity if heparin is applied simultaneously. After addition of heparin antidote polybrene the results are comparable with the reptilase time (so-called polybrene thrombin time). In the case of a fibrinolytic therapy it is recommended to use the thrombin time according to AB-D.L. (heparin-sensitive method) and the polybrene thrombin time (heparin-insensitive method).
凝血酶时间对于控制链激酶的纤维蛋白溶解疗法至关重要。但如果同时应用肝素，使用凝血酶时间来估计纤维蛋白溶解活性并不有效。加入肝素解毒剂鱼精蛋白后，结果与蛇凝血酶时间（所谓的鱼精蛋白凝血酶时间）相当。在纤维蛋白溶解疗法的情况下，建议根据AB-D.L.（肝素敏感法）使用凝血酶时间和鱼精蛋白凝血酶时间（肝素不敏感法）。
