自我意识和认知功能障碍在伴发和不伴发冲动控制障碍的帕金森病中的作用。
The role of self-awareness and cognitive dysfunction in Parkinson's disease with and without impulse-control disorder.
机构信息
Dept. of Psychiatry, Oregon Health and Science University, Portland, OR, USA.
出版信息
J Neuropsychiatry Clin Neurosci. 2013 Spring;25(2):141-9. doi: 10.1176/appi.neuropsych.12030076.
The aim of this study was to investigate the clinical, neuropsychological, and self-awareness correlates of impulse-control disorder (ICD) in a group of 17 Parkinson's disease (PD) subjects with an active ICD and a comparison group of 17 PD subjects without ICD. Self-awareness was assessed with the Beck Cognitive Insight Scale and patient-caregiver discrepancy scores from ratings on the Dysexecutive Questionnaire and the Everyday Memory Questionnaire-Revised. Self-awareness was comparable or increased in those with ICD, versus those without, and measures of neuropsychological functioning did not differ between the two groups. Those with ICD had more motor complications of PD therapy and were more likely to be on an antidepressant than those without ICD, whereas dopaminergic medication profiles were comparable between the two groups. In this group, PD patients with current ICDs were aware of their impulsivity. Although executive dysfunction may contribute to ICD behavior, it is not a necessary component. The awareness of the inability to resist these motivated behaviors may be a source of increased depression.
本研究旨在调查冲动控制障碍（ICD）在一组 17 名帕金森病（PD）患者中的临床、神经心理学和自我意识相关性，这些患者存在活跃的 ICD，以及一组 17 名没有 ICD 的 PD 患者作为对照组。自我意识通过贝克认知洞察量表进行评估，以及通过执行功能问卷和日常记忆问卷修订版对患者和照料者的评分来评估患者-照料者差异得分。与没有 ICD 的患者相比，有 ICD 的患者的自我意识相当或有所提高，并且两组之间的神经心理学功能测量结果没有差异。与没有 ICD 的患者相比，有 ICD 的患者的 PD 治疗运动并发症更多，服用抗抑郁药的可能性也更高，而两组的多巴胺能药物治疗方案相当。在该组中，患有 ICD 的 PD 患者意识到自己的冲动性。尽管执行功能障碍可能导致 ICD 行为，但它不是必要的组成部分。无法抗拒这些动机行为的意识可能是增加抑郁的一个来源。
Zotero 插件