Brakoulias Vlasios, Starcevic Vladan, Berle David, Sammut Peter, Milicevic Denise, Moses Karen, Hannan Anthony, Martin Andrew
Discipline of Psychiatry, Sydney Medical School-Nepean, University of Sydney, Sydney/Penrith, Australia.
J Nerv Ment Dis. 2013 Jun;201(6):452-9. doi: 10.1097/NMD.0b013e318294804e.
Attempts to explain the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) have resulted in three to six OCD symptom dimensions. This study aimed to clarify the nature of these symptom dimensions using a self-report instrument (Vancouver Obsessional Compulsive Inventory [VOCI]) in addition to the clinician-rated Yale-Brown Obsessive Compulsive Scale-Symptom Checklist (YBOCS-SC). Participants (N = 154) were recruited to a study designed to specifically assess OCD symptom dimensions. Symptoms assessed via the YBOCS-SC and the VOCI were subjected to principal components analysis (PCA). Linear regression was used to assess the relationship between the YBOCS-SC-derived symptom dimensions and the VOCI symptom subscales. PCA of the YBOCS-SC and the VOCI revealed five OCD symptom dimensions that explained 68% and 60% of the variance, respectively. The results also supported a distinction between the doubt/checking symptom dimension and the unacceptable/taboo thoughts dimension that includes mental rituals. The YBOCS-SC-derived symptom components were predicted by their respective VOCI symptom subscale scores.
为解释强迫症（OCD）的表型异质性，已得出三到六个强迫症症状维度。本研究旨在使用一份自我报告工具（温哥华强迫观念强迫行为量表[VOCI]）以及临床医生评定的耶鲁-布朗强迫量表-症状清单（YBOCS-SC）来阐明这些症状维度的本质。招募了154名参与者参加一项专门评估强迫症症状维度的研究。通过YBOCS-SC和VOCI评估的症状进行了主成分分析（PCA）。使用线性回归来评估源自YBOCS-SC的症状维度与VOCI症状子量表之间的关系。YBOCS-SC和VOCI的PCA揭示了五个强迫症症状维度，分别解释了68%和60%的方差。结果还支持怀疑/检查症状维度与包括心理仪式在内的不可接受/禁忌思维维度之间的区分。源自YBOCS-SC的症状成分可由各自的VOCI症状子量表分数预测。
