Ochoa Susana, Suarez David, Novick Diego, Arranz Belen, Roca Mercedes, Baño Vicente, Haro Josep Maria
Research Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Barcelona, Spain.
J Nerv Ment Dis. 2013 Jun;201(6):464-70. doi: 10.1097/NMD.0b013e31829480b0.
This analysis explored the prevalence, incidence, and predictors of hostility in the European Schizophrenia Outpatient Health Outcomes (EU-SOHO) study. Data were collected at baseline and up to 36 months on the presence of hostility, clinical course and severity, medication compliance, side effects, substance/alcohol abuse, and being a crime survivor. Regression models were fitted to test the association between predictors and the presence of hostility. Hostility prevalence in the 6 months before baseline was 27.9%, and the incidence at 3 years was 14.0%. Variables related to hostility during follow-up were age, male sex, alcohol/substance abuse, tardive dyskinesia, extrapyramidal symptoms, cognitive impairment, noncompliance, and hospitalization. Being a crime survivor, being married, not living independently, and not being in paid employment were associated with hostility at baseline. Clinical and social variables are related to hostility in schizophrenia. Extrapyramidal symptoms and tardive dyskinesia, alcohol/substance abuse, cognitive impairment, medication noncompliance, and hospitalizations are predictors of future hostility.
本分析在欧洲精神分裂症门诊健康结局（EU - SOHO）研究中探讨了敌意的患病率、发病率及预测因素。在基线期及长达36个月的时间里收集了有关敌意的存在情况、临床病程与严重程度、药物依从性、副作用、物质/酒精滥用以及是否为犯罪幸存者的数据。拟合回归模型以检验预测因素与敌意存在之间的关联。基线前6个月的敌意患病率为27.9%，3年时的发病率为14.0%。随访期间与敌意相关的变量有年龄、男性、酒精/物质滥用、迟发性运动障碍、锥体外系症状、认知障碍、不依从以及住院治疗。在基线期，身为犯罪幸存者、已婚、非独立生活以及无带薪工作与敌意相关。临床和社会变量与精神分裂症中的敌意有关。锥体外系症状和迟发性运动障碍、酒精/物质滥用、认知障碍、药物不依从以及住院治疗是未来敌意的预测因素。
