Addington J, Addington D
Department of Psychiatry, University of Calgary, Alberta, Canada.
J Psychiatry Neurosci. 1997 Mar;22(2):99-104.
Individuals with schizophrenia have an increased vulnerability to abuse drugs or alcohol. This vulnerability can interfere with the course and treatment of the disorder and may also have a detrimental effect on already compromised cognitive functioning. This study has a matched, cross-sectional design and compares the social and cognitive functioning and the symptoms of 33 schizophrenia subjects who abuse substances with 33 nonabusing schizophrenia subjects. Subjects were matched on sex, age, and education variables and were all outpatients. Measures of social functioning and quality of life were used. Assessment of cognitive functioning included measures of verbal ability, attention, executive functioning, and verbal and visual memory. Substance-abusing subjects had significantly lower quality of life. There were no other differences between the 2 groups. Several explanations are offered for the lack of observed differences in cognitive functioning.
精神分裂症患者滥用药物或酒精的易感性增加。这种易感性会干扰该疾病的病程和治疗，还可能对本已受损的认知功能产生不利影响。本研究采用匹配的横断面设计，比较了33名滥用物质的精神分裂症患者和33名不滥用物质的精神分裂症患者的社会和认知功能以及症状。受试者在性别、年龄和教育变量上进行了匹配，均为门诊患者。使用了社会功能和生活质量的测量方法。认知功能评估包括语言能力、注意力、执行功能以及语言和视觉记忆的测量。滥用物质的受试者生活质量显著较低。两组之间没有其他差异。针对在认知功能方面未观察到差异的情况给出了几种解释。
