重新发现 ACE：血管紧张素转换酶多种作用的新见解。
Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme.
机构信息
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
出版信息
J Mol Med (Berl). 2013 Oct;91(10):1143-54. doi: 10.1007/s00109-013-1051-z. Epub 2013 May 18.
Abstract
Angiotensin-converting enzyme (ACE) is best known for the catalytic conversion of angiotensin I to angiotensin II. However, the use of gene-targeting techniques has led to mouse models highlighting many other biochemical properties and actions of this enzyme. This review discusses recent studies examining the functional significance of ACE tissue-specific expression and the presence in ACE of two independent catalytic sites with distinct substrates and biological effects. It is these features which explain why ACE makes important contributions to many different physiological processes including renal development, blood pressure control, inflammation, and immunity.
摘要
血管紧张素转换酶（ACE）最为人熟知的是催化血管紧张素 I 转化为血管紧张素 II。然而，利用基因靶向技术已经产生了许多强调这种酶的其他生化特性和作用的小鼠模型。这篇综述讨论了最近的研究，这些研究检查了 ACE 组织特异性表达的功能意义，以及 ACE 中存在的两个具有不同底物和生物学效应的独立催化位点。正是这些特性解释了为什么 ACE 对许多不同的生理过程，包括肾脏发育、血压控制、炎症和免疫，都有重要的贡献。
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