Division of Nephrology, Department of Medicine, Cardiovascular Research Center, Duke University, Durham, North Carolina, USA.
Nat Med. 2011 Nov 7;17(11):1402-9. doi: 10.1038/nm.2541.
High blood pressure, or hypertension, is a very common disorder with a substantial impact on public health because of its associated complications. Despite the high prevalence of essential hypertension and years of research, the basic causes remain obscure. Here I review recent advances in understanding the pathophysiology of hypertension. I present a general overview of the field and, by necessity, use broad strokes to portray recent progress and place it in context. For this purpose, I use illustrative examples from the large number of important developments in hypertension research over the last five years. The intent of this review is to provide a sense of where the field is progressing, with an emphasis on work that sheds light on pathogenic mechanisms and that is therefore likely to inform new translational advances.
高血压，又称高血压，是一种非常常见的疾病，由于其相关并发症，对公众健康有重大影响。尽管原发性高血压的患病率很高，而且研究也进行了多年，但基本病因仍不清楚。在这里，我回顾了近年来对高血压病理生理学的理解进展。我对该领域进行了概述，并且为了描绘近期进展并将其置于适当的背景下，不可避免地采用了宽泛的笔触。为此，我使用了过去五年高血压研究中大量重要进展的例子。这篇综述的目的是提供对该领域进展情况的了解，重点是阐明发病机制的工作，因此可能为新的转化进展提供信息。
