Unit of Human Genetics, Institute of Clinical Research, University of Southern Denmark, Odense C, Denmark.
Obesity (Silver Spring). 2013 Sep;21(9):1908-14. doi: 10.1002/oby.20217. Epub 2013 May 19.
A twin-based comparative study on the genetic influences in metabolic endophenotypes in two populations of substantial ethnic, environmental, and cultural differences was performed.
Data on 11 metabolic phenotypes including anthropometric measures, blood glucose, and lipids levels as well as blood pressure were available from 756 pairs of Danish twins (309 monozygotic and 447 dizygotic twin pairs) with a mean age of 38 years (range: 18-67) and from 325 pairs of Chinese twins (183 monozygotic and 142 dizygotic twin pairs) with a mean age of 40.5 years (range: 18-69). Twin modeling was performed on full and nested models with the best fitting models selected.
Heritability estimates were compared between Danish and Chinese samples to identify differential genetic influences on each of the phenotypes. Except for hip circumference, all other body measures exhibited similar heritability patterns in the two samples with body weight showing only a slight difference. Higher genetic influences were estimated for fasting blood glucose level in Chinese twins, whereas the Danish twins showed more genetic regulation over most lipids phenotypes. Systolic blood pressure was more genetically controlled in Danish than in Chinese twins.
Metabolic endophenotypes show disparity in their genetic determinants in populations under distinct environmental conditions.
对两个具有显著种族、环境和文化差异的人群中的代谢内表型的遗传影响进行基于双胞胎的比较研究。
从 756 对丹麦双胞胎（309 对同卵双胞胎和 447 对异卵双胞胎）中获得了包括人体测量指标、血糖和血脂水平以及血压在内的 11 种代谢表型的数据，这些双胞胎的平均年龄为 38 岁（范围：18-67），从 325 对中国双胞胎（183 对同卵双胞胎和 142 对异卵双胞胎）中获得了数据，这些双胞胎的平均年龄为 40.5 岁（范围：18-69）。对完整和嵌套模型进行了双胞胎建模，并选择了最佳拟合模型。
比较了丹麦和中国样本中的遗传力估计值，以确定每种表型的遗传影响是否存在差异。除臀围外，所有其他身体指标在两个样本中均表现出相似的遗传模式，体重仅略有差异。中国双胞胎的空腹血糖水平遗传影响较高，而丹麦双胞胎对大多数血脂表型的遗传调控更为明显。丹麦双胞胎的收缩压受遗传控制的程度高于中国双胞胎。
在不同环境条件下的人群中，代谢内表型的遗传决定因素存在差异。
