胎儿及新生儿同种免疫性血小板减少症
Fetal and neonatal alloimmune thrombocytopenia.
作者信息
Espinoza J P, Caradeux J, Norwitz Errol R, Illanes S E
机构信息
Department of Obstetrics & Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de Los Andes, Chile.
出版信息
Rev Obstet Gynecol. 2013;6(1):e15-21.
Abstract
Fetomaternal alloimmune thrombocytopenia (FMAIT) is a relatively uncommon disease, but is the leading cause of severe thrombocytopenia in the newborn. It can cause severe complications and long-term disabilities. The main objective of screening is to reduce both the morbidity and mortality associated with FMAIT, primarily by preventing intracranial hemorrhage. However, controversy surrounds both pre- and antenatal management. This article discusses pathogenesis, screening, diagnosis, and both pre- and neonatal management of FMAIT.
摘要
胎儿母体同种免疫性血小板减少症（FMAIT）是一种相对罕见的疾病，但却是新生儿严重血小板减少症的主要原因。它可导致严重并发症和长期残疾。筛查的主要目的是降低与FMAIT相关的发病率和死亡率，主要是通过预防颅内出血。然而，产前和产后管理都存在争议。本文讨论了FMAIT的发病机制、筛查、诊断以及产前和新生儿管理。
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