Uenaka Mizuki, Morizane Mayumi, Tanimura Kenji, Deguchi Masashi, Ebina Yasuhiko, Hashimoto Makoto, Morioka Ichiro, Yamada Hideto
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
Department of Transfusion Medicine and Cell Therapy, Kobe University Hospital, Kobe, Japan.
Kobe J Med Sci. 2019 Mar 5;64(6):E197-E199.
Antibodies against fetal platelet alloantigens in maternal blood cause neonatal alloimmune thrombocytopenia (NAIT). We encountered four newborns with NAIT from three women. A woman carried anti-human platelet antigen (HPA)-1a antibody, and vaginally delivered a newborn who had subarachnoid hemorrhage and platelet transfusions. She delivered the second newborn by a cesarean section who had no symptom. The second woman carried anti-human leukocyte antigen-A2 antibody and vaginally delivered a newborn who had no symptom. The third woman with a history of recurrent pregnancy losses carried anti-HPA-4b antibody, and delivered a newborn by a cesarean section who received platelet transfusions and immunoglobulin infusions. Antiplatelet antibody screening may be helpful in women who have a history of blood transfusion, or previous neonates with thrombocytopenia or intracranial hemorrhage.
母体血液中针对胎儿血小板同种抗原的抗体可导致新生儿同种免疫性血小板减少症（NAIT）。我们遇到了来自三名女性的四名患有NAIT的新生儿。一名女性携带抗人血小板抗原（HPA）-1a抗体，经阴道分娩了一名患有蛛网膜下腔出血并接受了血小板输血的新生儿。她通过剖宫产分娩了第二名无症状的新生儿。第二名女性携带抗人白细胞抗原-A2抗体，经阴道分娩了一名无症状的新生儿。第三名有反复流产史的女性携带抗HPA-4b抗体，通过剖宫产分娩了一名接受了血小板输血和免疫球蛋白输注的新生儿。抗血小板抗体筛查可能有助于有输血史、或之前有新生儿血小板减少症或颅内出血的女性。
