儿童艰难梭菌感染：现状与未解决的问题
Clostridium difficile Infection in Children: Current State and Unanswered Questions.
作者信息
Tamma Pranita D, Sandora Thomas J
机构信息
Johns Hopkins Medical Institutions, Division of Pediatric Infectious Diseases, Department of Pediatrics, Baltimore, Maryland;
Boston Children's Hospital, Division of Infectious Diseases, Departments of Medicine and Laboratory Medicine, Massachusetts.
出版信息
J Pediatric Infect Dis Soc. 2012 Sep;1(3):230-43. doi: 10.1093/jpids/pis071. Epub 2012 Jul 25.
The incidence of Clostridium difficile infection (CDI) in children has increased over the past decade. In recent years, new and intriguing data on pediatric CDI have emerged. Community-onset infections are increasingly recognized, even in children who have not previously received antibiotics. A hypervirulent strain is responsible for up to 20% of pediatric CDI cases. Unique risk factors for CDI in children have been identified. Advances in diagnostic testing strategies, including the use of nucleic acid amplification tests, have raised new questions about the optimal approach to diagnosing CDI in children. Novel therapeutic options are available for adult patients with CDI, raising questions about the use of these agents in children. Updated recommendations about infection prevention and control measures are now available. We summarize these recent developments in pediatric CDI in this review and also highlight remaining knowledge gaps that should be addressed in future research efforts.
在过去十年中，儿童艰难梭菌感染（CDI）的发病率有所上升。近年来，出现了关于儿童CDI的新的有趣数据。社区获得性感染越来越受到认可，即使在以前未接受过抗生素治疗的儿童中也是如此。一种高毒力菌株导致高达20%的儿童CDI病例。已确定儿童CDI的独特危险因素。诊断测试策略的进展，包括使用核酸扩增测试，对儿童CDI的最佳诊断方法提出了新问题。成人CDI患者有新的治疗选择，这也引发了这些药物在儿童中使用的问题。现在有了关于感染预防和控制措施的更新建议。在本综述中，我们总结了儿童CDI的这些最新进展，并强调了未来研究中应解决的剩余知识空白。
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