粪便毒素浓度不能区分小于 3 岁儿童的艰难梭菌感染和定植。
Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age.
机构信息
Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts, USA.
出版信息
J Pediatric Infect Dis Soc. 2022 Oct 25;11(10):454-458. doi: 10.1093/jpids/piac059.
Abstract
In a prospective cohort study, stools from children <3 years with and without diarrhea who were Clostridioides difficile nucleic acid amplification test-positive underwent ultrasensitive and quantitative toxin measurement. Among 37 cases and 46 controls, toxin concentration distributions overlapped substantially. Toxin concentration alone does not distinguish C. difficile infection from colonization in young children.
摘要
在一项前瞻性队列研究中，对核酸扩增试验阳性的<3 岁腹泻和非腹泻儿童的粪便进行超敏和定量毒素检测。在 37 例病例和 46 例对照中，毒素浓度分布有很大的重叠。单独的毒素浓度不能区分幼儿的艰难梭菌感染和定植。
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