Department of Obstetrics and Gynaecology, Shanghai Jiao Tong University, Shanghai, China.
Reprod Biol Endocrinol. 2013 May 20;11:46. doi: 10.1186/1477-7827-11-46.
Cases of ectopic pregnancy (EP) following levonorgestrel (LNG) emergency contraception (EC) failure were reported, however, the effects of LNG on tubal microenvironment or chorionic villi in EP have not yet been documented.
Fifty-five women with tubal pregnancy were divided into two groups according to whether LNG-EC was administrated during the cycle of conception. The serum concentrations of beta-hCG, E2 and P were measured. The mRNA and protein expressions of estrogen and progesterone receptors, leukemia inhibitory factor, vascular endothelial growth factor, inducible nitric oxide synthase, and endocannabinoid receptor - CB1 in the ectopic implantation site and chorionic villi were examined.
Compared to those unexposed to LNG-EC, women with tubal pregnancy exposed to LNG-EC during the cycle of conception had no statistically significances in the serum concentrations of beta-hCG, E2 P, nor in the pathological types of tubal pregnancy or the expressions of ER-alpha, PR, LIF, VEGF, iNOS and CB1.
The expressions of candidate molecules in the fallopian tube and chorionic villi were not altered by exposure to LNG-EC. A routine therapy with no additional intervention might thus be applied to tubal pregnancy exposed to LNG-EC.
曾有报道称，左炔诺孕酮（LNG）紧急避孕（EC）失败后会发生异位妊娠（EP），但 LNG 对 EP 输卵管微环境或绒毛的影响尚未有文献记载。
根据受孕周期是否使用 LNG-EC，将 55 例输卵管妊娠患者分为两组。检测血清β-hCG、E2 和 P 浓度，检测异位着床部位和绒毛中雌激素和孕激素受体、白血病抑制因子、血管内皮生长因子、诱导型一氧化氮合酶、内源性大麻素受体 - CB1 的 mRNA 和蛋白表达。
与未接触 LNG-EC 的患者相比，受孕周期接触 LNG-EC 的输卵管妊娠患者血清β-hCG、E2、P 浓度、输卵管妊娠的病理类型以及 ER-α、PR、LIF、VEGF、iNOS 和 CB1 的表达均无统计学意义。
暴露于 LNG-EC 并未改变输卵管和绒毛中候选分子的表达。因此，对于暴露于 LNG-EC 的输卵管妊娠，可以采用常规治疗而无需额外干预。
