Lee Jae Ho, Noh Geunwoong
Department of Pediatrics, Chungnam National University, Daejeon, Korea.
Inflamm Allergy Drug Targets. 2013 Jun;12(3):212-20. doi: 10.2174/1871528111312030009.
Atopic dermatitis (AD) is a chronic allergic inflammatory disease characterised by late eczematous lesions and allergenic sensitisation that occur. Skin prick testing has been used for the causative investigation of individual allergens. However, there exists no proper tool to evaluate polysensitisation status. In this study, skin sensitisation indices were suggested, and the clinical significance of polysensitisation was evaluated.
A total of 188 AD patients were involved in this study. Blood tests including blood eosinophil % and serum total IgE were conducted. Skin prick tests for 50 important allergens were performed. The skin sensitisation index (SSI) was compared with the blood eosinophil % and the serum total IgE.
The degree of sensitisation may be related to the serum total IgE rather than the number of allergens to which a patient is sensitised. The skin sensitisation profile was associated with IgE-related laboratory results but not with clinical activity or blood eosinophil %.
For the evaluation of polysensitisation, skin sensitisation profiles may be needed and the skin sensitisation profile was useful for the description of polysensitisation. Polysensitisation seems to be one mechanism for the elevation of serum total IgE. Further studies may be needed to ascertain the clinical significance of skin polysensitisation and the application of the skin sensitisation profile in clinical use.
特应性皮炎（AD）是一种慢性过敏性炎症性疾病，其特征为出现晚期湿疹样皮损和变应原致敏。皮肤点刺试验已用于个体变应原的病因学调查。然而，目前尚无评估多致敏状态的合适工具。在本研究中，提出了皮肤致敏指数，并评估了多致敏的临床意义。
本研究共纳入188例AD患者。进行了包括血嗜酸性粒细胞百分比和血清总IgE在内的血液检查。对50种重要变应原进行了皮肤点刺试验。将皮肤致敏指数（SSI）与血嗜酸性粒细胞百分比和血清总IgE进行比较。
致敏程度可能与血清总IgE有关，而非与患者致敏的变应原数量有关。皮肤致敏谱与IgE相关的实验室检查结果相关，但与临床活动或血嗜酸性粒细胞百分比无关。
为评估多致敏，可能需要皮肤致敏谱，且皮肤致敏谱有助于描述多致敏情况。多致敏似乎是血清总IgE升高的一种机制。可能需要进一步研究以确定皮肤多致敏的临床意义以及皮肤致敏谱在临床应用中的价值。
