Department of Otorhinolaryngology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwon-do, Republic of Korea.
Eur Arch Otorhinolaryngol. 2023 Sep;280(9):4121-4129. doi: 10.1007/s00405-023-07968-0. Epub 2023 Apr 11.
Accumulating evidence suggests that Staphylococcus aureus plays a significant role as a disease modifier in upper and lower airway diseases. We aimed to assess the association between staphylococcal enterotoxins (SEs) with allergic diseases and the degree of allergen sensitisation in children, which remains unclear.
We retrospectively reviewed the medical records of 455 patients aged 3-18 years between March 2018 and March 2022. Clinical history and demographic data were obtained. The baseline study included paranasal sinus X-ray scan, multiple allergen simultaneous test, and ImmunoCAP® for measuring serum total and specific immunoglobulin E (IgE) levels to allergens and staphylococcal enterotoxin A and B (SEA and SEB).
The mean age was 9.77 ± 4.3 years. 133 patients (29.2%) were sensitised to one inhalant allergen, and 188 patients (41.3%) showed polysensitisation. Patients sensitised to SEs showed higher total and specific IgE levels and total eosinophil counts compared to non-SE-sensitised patients. Sensitisation to SEs is closely associated with polysensitisation to inhalant allergens and allergic multimorbidity. When the SE-IgE value was 0.35 or higher, the odds ratio for allergen polysensitisation was significantly higher than when the SE-IgE value was lower than 0.35.
Association between polysensitisation and sensitisation to SEs in children shows the higher the specific IgE levels for SEs, the higher the likelihood of polysensitisation. Considering the relationship between polysensitisation, high IgE levels, and the severity of allergic morbidity, sensitisation to SEs is thought to be related to allergy severity.
越来越多的证据表明金黄色葡萄球菌在上下呼吸道疾病中作为疾病修饰因子发挥着重要作用。我们旨在评估金黄色葡萄球菌肠毒素（SE）与儿童过敏性疾病和过敏原致敏程度的相关性，这一点尚不清楚。
我们回顾性分析了 2018 年 3 月至 2022 年 3 月期间 455 名 3-18 岁患者的病历。获取临床病史和人口统计学数据。基线研究包括鼻窦 X 射线扫描、多种过敏原同时检测和 ImmunoCAP®，用于测量血清总和特异性免疫球蛋白 E（IgE）水平对过敏原和金黄色葡萄球菌肠毒素 A 和 B（SEA 和 SEB）的。
平均年龄为 9.77±4.3 岁。133 名患者（29.2%）对一种吸入性过敏原敏感，188 名患者（41.3%）表现出多敏化。与非 SE 致敏患者相比，SE 致敏患者的总 IgE 和特异性 IgE 水平以及总嗜酸性粒细胞计数更高。SE 致敏与吸入性过敏原的多敏化和过敏性多种疾病密切相关。当 SE-IgE 值为 0.35 或更高时，过敏原多敏化的优势比明显高于 SE-IgE 值低于 0.35 时。
儿童多敏化与 SE 致敏之间的关联表明，SE 的特异性 IgE 水平越高，多敏化的可能性就越高。考虑到多敏化、高 IgE 水平和过敏发病严重程度之间的关系，SE 致敏被认为与过敏严重程度有关。
