VEGF 和 IL-8 在肺癌恶性胸腔积液患者中的预后价值。
Prognostic values of VEGF and IL-8 in malignant pleural effusion in patients with lung cancer.
机构信息
Department of Transfusion, The First Hospital of China Medical University, Shenyang, Liaoning Province, PR China.
出版信息
Biomarkers. 2013 Aug;18(5):386-90. doi: 10.3109/1354750X.2013.797499. Epub 2013 May 20.
OBJECTIVE
The aim of this study was to evaluate the prognostic value of VEGF and IL-8 in pleural effusion in patients with lung cancer.
MATERIALS AND METHOD
Commercially available ELISA was used to determine VEGF and IL-8 levels.
RESULTS
The level of VEGF showed significant correlations with lymph node metastasis and distant metastasis. But, IL-8 was only correlated with lymph node metastasis. Univariate and multivariate analysis revealed elevated VEGF level was an independent predictor of shorter OS and DFS.
CONCLUSION
VEGF could be an important component that contributes to pleural effusion formation, and an important prognostic factor for lung cancer.
目的
本研究旨在评估血管内皮生长因子（VEGF）和白细胞介素-8（IL-8）在肺癌患者胸腔积液中的预后价值。
材料和方法
采用商品化酶联免疫吸附试验（ELISA）测定 VEGF 和 IL-8 水平。
结果
VEGF 水平与淋巴结转移和远处转移显著相关。而 IL-8 仅与淋巴结转移相关。单因素和多因素分析显示，VEGF 水平升高是总生存期（OS）和无进展生存期（DFS）较短的独立预测因子。
结论
VEGF 可能是胸腔积液形成的重要组成部分，也是肺癌的重要预后因素。
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