血清组织金属蛋白酶抑制剂 1（TIMP-1）和血管内皮生长因子 A（VEGF-A）与食管癌患者的预后相关。

Serum tissue inhibitor of metalloproteinase 1 (TIMP-1) and vascular endothelial growth factor A (VEGF-A) are associated with prognosis in esophageal cancer patients.

出版信息

Adv Med Sci. 2013;58(2):227-34. doi: 10.2478/ams-2013-0017.

DOI:10.2478/ams-2013-0017

Abstract

PURPOSE

The matrix metalloproteinases, tissue inhibitors of metalloproteinases and angiogenesis contribute to growth and spread of cancer. We investigated the correlation between pretreatment serum levels of tissue inhibitor of metalloproteinase 1 (TIMP-1) and vascular endothelial growth factor A (VEGF-A), and clinicopathologic features and survival in patients with esophageal cancer (EC).

MATERIAL/METHODS: Serum TIMP-1 and VEGF-A were measured by enzyme-linked immunosorbent assay (ELISA) in 89 patients with EC, and 30 healthy controls.

RESULTS

Serum TIMP-1 and VEGF-A levels were significantly higher in patients with esophageal carcinoma than in the control group (p=0.001 and p<0.001, respectively). High levels of TIMP-1 were associated with histological type (p<0.001), tumor depth (p<0.001), stage (p<0.001) and lymph node metastases (p=0.001). Subgroup analysis showed that tumor size (p<0.001), tumor depth (p<0.001), stage (p<0.001), lymph node metastases (p=0.002), distant metastases (p=0.009) and resectability (p=0.003), were correlated with an elevated level of VEGF-A. Patients with elevated levels of TIMP-1 and VEGF-A had a significantly lower overall survival (p=0.02 and p=0.048, respectively), and disease-free survival (TIMP-1, p<0.001).

CONCLUSION

High serum levels of TIMP-1 and VEGF-A were found to be associated with tumor progression and unfavorable prognosis in patients with EC.

摘要

目的

基质金属蛋白酶、金属蛋白酶组织抑制剂和血管生成与癌症的生长和扩散有关。我们研究了食管癌患者治疗前血清组织抑制剂 1（TIMP-1）和血管内皮生长因子 A（VEGF-A）水平与临床病理特征和生存的相关性。

材料/方法：采用酶联免疫吸附试验（ELISA）检测 89 例食管癌患者和 30 例健康对照者血清 TIMP-1 和 VEGF-A 水平。

结果

食管癌患者血清 TIMP-1 和 VEGF-A 水平明显高于对照组（p=0.001 和 p<0.001）。高水平的 TIMP-1 与组织学类型（p<0.001）、肿瘤深度（p<0.001）、分期（p<0.001）和淋巴结转移（p=0.001）有关。亚组分析显示，肿瘤大小（p<0.001）、肿瘤深度（p<0.001）、分期（p<0.001）、淋巴结转移（p=0.002）、远处转移（p=0.009）和可切除性（p=0.003）与 VEGF-A 水平升高相关。TIMP-1 和 VEGF-A 水平升高的患者总生存率（p=0.02 和 p=0.048）和无病生存率（TIMP-1，p<0.001）明显降低。