[鱼类摄入量与肾细胞癌风险的荟萃分析]

[A meta-analysis of fish intake and the risk of renal cell cancer].

作者信息

Wan Pei, Li Yan, Li Fei, Ma Tianjun, Lan Kaijian, Chen Wei, Chen Sansan, He Chengwu, Tan Wanlong

机构信息

Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2013 May;33(5):772-5.

PMID:23689005

Abstract

OBJECTIVE

To explore the association of fish intake with the risk of renal cancer.

METHODS

PubMed, Embase, CNKI and CA databases were searched for case-control studies or cohort studies examining the relationship between fish or fish products intake and renal cancer. Heterogeneity among the selected studies was assessed using I2 score, and the publication bias was assessed using funnel plots.

RESULTS

Seventeen articles were included in the analysis with a heterogeneity across the studies (P=0.003, I(2)=52.3%). A random-effects model was used to generate the pooled risk ratio (RR) and 95% confidence interval (CI), and no statistically significant association was found between the risk of renal cancer and fish intake (RR=0.90; 95% CI, 0.78-1.02). In subgroup analysis, no evidence was found that the study design, study region or publication date influenced the results; but in the gender subgroup analysis, fish intake we found to decrease the risk of renal cancer in men but not in women.

CONCLUSION

The results of meta-analysis do not support an association between fish intake and a lowered risk of renal cancer.

摘要

目的

探讨鱼类摄入量与肾癌风险之间的关联。

方法

检索PubMed、Embase、中国知网（CNKI）和《化学文摘》（CA）数据库，查找检验鱼类或鱼类产品摄入量与肾癌之间关系的病例对照研究或队列研究。使用I2评分评估所选研究之间的异质性，并使用漏斗图评估发表偏倚。

结果

17篇文章纳入分析，研究之间存在异质性（P = 0.003，I(2)=52.3%）。采用随机效应模型生成合并风险比（RR）和95%置信区间（CI），未发现肾癌风险与鱼类摄入量之间存在统计学显著关联（RR = 0.90；95% CI，0.78 - 1.02）。在亚组分析中，未发现研究设计、研究地区或发表日期对结果有影响；但在性别亚组分析中，发现鱼类摄入量可降低男性患肾癌的风险，而对女性则无此影响。