Department of Nephrology, Shandong Weifang People's Hospital, Weifang, China.
PLoS One. 2013 Oct 28;8(10):e75732. doi: 10.1371/journal.pone.0075732. eCollection 2013.
Epidemiologic studies have evaluated the association between cruciferous vegetables(CV) intake and the risk of renal cell carcinoma(RCC); however, the existing results are controversial. The aim of this meta-analysis was to investigate the association between CV intake and RCC risk.
A literature search was carried out using PUBMED and EMBASE database between January 1966 and March 2013. Fixed-effect and random-effect models were used to estimate summary relative risks (RR) and the corresponding 95% confidence intervals (CIs). Potential sources of heterogeneity were detected by meta-regression. Subgroup analyses, sensitivity analysis and cumulative meta-analysis were also performed.
A total of 12 studies (six cohorts, six case-control) contributed to the analysis, involving 1,228,518 participants and 5,773 RCC cases. When all studies were pooled, we observed a significantly inverse association between CV intake and RCC risk (RR = 0.81, 95% CI [0.72, 0.91]). This association was also significant when analyses were restricted to six high-quality studies (RR = 0.89, 95% CI [0.82, 0.98]). In subgroup analyses, CV intake was significantly associated with reduced RCC risk among studies conducted in America (RR = 0.77, 95%CI [0.70, 0.86]); however, CV intake had no significant association with RCC risk among studies conducted in Europe (RR = 0.87, 95%CI [0.71, 1.07]). Furthermore, sensitivity analysis confirmed the stability of results.
The findings of this meta-analysis suggested that high intake of CV was inversely associated with RCC risk among Americans. More studies, especially high quality cohort studies with larger sample size, well controlled confounding factors are warranted to confirm this association.
流行病学研究评估了十字花科蔬菜（CV）摄入量与肾细胞癌（RCC）风险之间的关联，但现有结果存在争议。本荟萃分析的目的是研究 CV 摄入量与 RCC 风险之间的关联。
使用 PUBMED 和 EMBASE 数据库，从 1966 年 1 月至 2013 年 3 月进行文献检索。使用固定效应和随机效应模型估计汇总相对风险（RR）及其相应的 95%置信区间（CI）。通过荟萃回归检测潜在的异质性来源。还进行了亚组分析、敏感性分析和累积荟萃分析。
共有 12 项研究（6 项队列研究，6 项病例对照研究）参与了分析，涉及 1228518 名参与者和 5773 例 RCC 病例。当所有研究合并时，我们观察到 CV 摄入量与 RCC 风险之间存在显著的负相关关系（RR=0.81，95%CI [0.72，0.91]）。当分析仅限于 6 项高质量研究时，这种关联仍然显著（RR=0.89，95%CI [0.82，0.98]）。在亚组分析中，CV 摄入量与美国研究中 RCC 风险降低显著相关（RR=0.77，95%CI [0.70，0.86]）；然而，CV 摄入量与欧洲研究中 RCC 风险之间没有显著关联（RR=0.87，95%CI [0.71，1.07]）。此外，敏感性分析证实了结果的稳定性。
本荟萃分析的结果表明，美国人 CV 摄入量高与 RCC 风险呈负相关。需要更多的研究，特别是高质量的队列研究，具有更大的样本量和更好的控制混杂因素，以证实这种关联。
