School of Population Health, University of Queensland, Herston, Australia.
Curr Opin Psychiatry. 2013 Jul;26(4):376-83. doi: 10.1097/YCO.0b013e328361e60f.
The Global Burden of Disease study 2010 (GBD 2010) estimated regional and global burden of 291 diseases and 67 risk factors. Here, we provide an overview of the methodological approach taken to this work, as well as the challenges and limitations encountered in deriving the burden of mental and drug use disorders.
GBD 2010 estimated the burden of 11 mental disorders and four drug use disorders for 21 regions. This involved a systematic literature search for epidemiological data; setting lay case definitions; synthesizing available epidemiological data into an internally consistent disease model; and quantifying the associated disability and health outcomes, to derive region, sex, year and age-specific burden estimates. Notable challenges included the difficulty in deriving culturally comparable case definitions for mental and drug use disorders, the paucity of epidemiological data and the difficulty in capturing disability associated with mental and drug use disorders.
GBD 2010 findings demonstrated the major public health importance of mental and drug use disorders. The methodology used to estimate burden was more sophisticated than previous GBD studies, with some restrictions required in order to achieve defensible numerical measures of burden for mental and drug use disorders.
2010 年全球疾病负担研究（GBD 2010）估计了 291 种疾病和 67 种风险因素在各区域和全球的负担。本文概述了开展这项工作所采用的方法学方法，以及在评估精神和药物使用障碍负担时遇到的挑战和限制。
GBD 2010 为 21 个区域估计了 11 种精神障碍和 4 种药物使用障碍的负担。这涉及到对流行病学数据进行系统文献检索；设定外行病例定义；将现有流行病学数据综合到一个内部一致的疾病模型中；以及量化相关残疾和健康结局，以得出区域、性别、年份和年龄特异性负担估计。值得注意的挑战包括为精神和药物使用障碍制定文化上可比的病例定义的困难、流行病学数据的缺乏以及难以捕捉与精神和药物使用障碍相关的残疾。
GBD 2010 的研究结果表明精神和药物使用障碍对公共卫生具有重要意义。用于估计负担的方法比以前的 GBD 研究更为复杂，为了对精神和药物使用障碍的负担进行合理的数值衡量，需要进行一些限制。
