Steel Zachary, Marnane Claire, Iranpour Changiz, Chey Tien, Jackson John W, Patel Vikram, Silove Derrick
Psychiatry Research and Teaching Unit, School of Psychiatry, University of New South Wales, NSW, Australia, Centre for Population Mental Health Research, South West Sydney Local District Network, Sydney, NSW, Australia, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Centre for Global Mental Health, London School of Hygiene and Tropical Medicine, London, UK, Centre for Mental Health, Public Health Foundation of India and Sangath, Goa, India.
Int J Epidemiol. 2014 Apr;43(2):476-93. doi: 10.1093/ije/dyu038. Epub 2014 Mar 19.
Since the introduction of specified diagnostic criteria for mental disorders in the 1970s, there has been a rapid expansion in the number of large-scale mental health surveys providing population estimates of the combined prevalence of common mental disorders (most commonly involving mood, anxiety and substance use disorders). In this study we undertake a systematic review and meta-analysis of this literature.
We applied an optimized search strategy across the Medline, PsycINFO, EMBASE and PubMed databases, supplemented by hand searching to identify relevant surveys. We identified 174 surveys across 63 countries providing period prevalence estimates (155 surveys) and lifetime prevalence estimates (85 surveys). Random effects meta-analysis was undertaken on logit-transformed prevalence rates to calculate pooled prevalence estimates, stratified according to methodological and substantive groupings.
Pooling across all studies, approximately 1 in 5 respondents (17.6%, 95% confidence interval:16.3-18.9%) were identified as meeting criteria for a common mental disorder during the 12-months preceding assessment; 29.2% (25.9-32.6%) of respondents were identified as having experienced a common mental disorder at some time during their lifetimes. A consistent gender effect in the prevalence of common mental disorder was evident; women having higher rates of mood (7.3%:4.0%) and anxiety (8.7%:4.3%) disorders during the previous 12 months and men having higher rates of substance use disorders (2.0%:7.5%), with a similar pattern for lifetime prevalence. There was also evidence of consistent regional variation in the prevalence of common mental disorder. Countries within North and South East Asia in particular displayed consistently lower one-year and lifetime prevalence estimates than other regions. One-year prevalence rates were also low among Sub-Saharan-Africa, whereas English speaking counties returned the highest lifetime prevalence estimates.
Despite a substantial degree of inter-survey heterogeneity in the meta-analysis, the findings confirm that common mental disorders are highly prevalent globally, affecting people across all regions of the world. This research provides an important resource for modelling population needs based on global regional estimates of mental disorder. The reasons for regional variation in mental disorder require further investigation.
自20世纪70年代引入精神障碍的特定诊断标准以来,提供常见精神障碍(最常见的包括情绪、焦虑和物质使用障碍)综合患病率人群估计的大规模心理健康调查数量迅速增加。在本研究中,我们对该文献进行了系统综述和荟萃分析。
我们在Medline、PsycINFO、EMBASE和PubMed数据库中应用了优化的搜索策略,并辅以手工检索以识别相关调查。我们在63个国家中识别出174项调查,这些调查提供了期间患病率估计值(155项调查)和终生患病率估计值(85项调查)。对经对数转换的患病率进行随机效应荟萃分析,以计算合并患病率估计值,并根据方法学和实质性分组进行分层。
汇总所有研究,在评估前的12个月内,约五分之一的受访者(17.6%,95%置信区间:16.3 - 18.9%)被确定符合常见精神障碍的标准;29.2%(25.9 - 32.6%)的受访者被确定在其一生中的某个时候经历过常见精神障碍。常见精神障碍患病率中明显存在一致的性别效应;在前12个月中,女性的情绪障碍(7.3%:4.0%)和焦虑障碍(8.7%:4.3%)患病率较高,而男性的物质使用障碍患病率较高(2.0%:7.5%),终生患病率也有类似模式。也有证据表明常见精神障碍患病率存在一致的区域差异。特别是东亚和东南亚国家的一年期和终生患病率估计值始终低于其他地区。撒哈拉以南非洲地区的一年期患病率也较低,而英语国家的终生患病率估计值最高。
尽管荟萃分析中各调查之间存在很大程度的异质性,但研究结果证实常见精神障碍在全球范围内高度流行,影响着世界所有地区的人们。这项研究为基于全球区域精神障碍估计值来模拟人群需求提供了重要资源。精神障碍区域差异的原因需要进一步调查。