Whittle T, Lucas C E, Ledgerwood A M, Weaver A, al-Sarraf M, Guan Z X, Grabow D
Department of Surgery, Wayne State University, Detroit, Michigan.
Am Surg. 1990 Jul;56(7):407-11.
The effects of cisplatin and 5-fluorouracil on wound breaking strength and the rate of closure of an orocutaneous fistula were studied in 80 male rodents. Treatment rats received a total of 4.6 mg/kg cisplatin and 62 mg/kg 5-fluorouracil in six doses/12 days; control rats received 0.9 per cent saline. After treatment, 30 treatment and 30 control rats received a dorsal skin incision which was closed primarily. Wound breaking strength were tested at one, three and five weeks in ten rats from each group. An 8-mm orocutaneous fistula was made in the remaining ten treatment and ten control rats; the rate of closure was noted weekly. Cisplatin and 5-fluorouracil did not significantly impair wound breaking strength at one, three, or five weeks. The rate of closure of the orocutaneous fistula was not effected by cisplatin/5-fluorouracil. The chemotherapy caused severe facial cellulitis and death in four orocutaneous fistula rats. Combined chemotherapy with cisplatin and 5-fluorouracil should not interfere with planned surgical care of head and neck tumors. Concomitant antibiotic coverage, however, is advocated.
在80只雄性啮齿动物身上研究了顺铂和5-氟尿嘧啶对伤口抗破裂强度和口腔皮肤瘘管闭合率的影响。治疗组大鼠在12天内分6次共接受4.6mg/kg顺铂和62mg/kg 5-氟尿嘧啶；对照组大鼠接受0.9%生理盐水。治疗后，30只治疗组和30只对照组大鼠接受背部皮肤切口并一期缝合。每组10只大鼠在第1、3和5周测试伤口抗破裂强度。其余10只治疗组和10只对照组大鼠制作8mm的口腔皮肤瘘管；每周记录闭合率。顺铂和5-氟尿嘧啶在第1、3或5周时对伤口抗破裂强度没有显著损害。口腔皮肤瘘管的闭合率不受顺铂/5-氟尿嘧啶的影响。化疗导致4只口腔皮肤瘘管大鼠出现严重面部蜂窝织炎并死亡。顺铂和5-氟尿嘧啶联合化疗不应干扰头颈肿瘤的计划手术治疗。然而，提倡同时使用抗生素。
