术前阿霉素和二羟基蒽二酮对伤口愈合的影响。

The effect of preoperative adriamycin and dihydroxyanthracenedione on wound healing.

作者信息

Mullen B M, Mattox D E, Von Hoff D D, Hearne E M

出版信息

Laryngoscope. 1981 Sep;91(9 Pt 1):1436-43.

Abstract

Preoperative adjuvant chemotherapy is being used with increasing frequency in advanced head and neck cancer; however, the effects of chemotherapy on wound healing have not been fully elucidated. To evaluate the effect of preoperative chemotherapy, experimental animals were given chemotherapeutic drugs, wounded, and the subsequent wound breaking strength determined. Rats received a single dose of intravenous tumoricidal drugs (adriamycin or or dihydroxyanthracenedione) either one week before or simultaneously with wounding. Wound breaking strength of treated animals and control animals receiving no chemotherapy was measured one and two weeks after wounding. All wounds, regardless of treatment, were stronger at two weeks than at one week after wounding. Wound breaking strength was reduced at both times when chemotherapy was administered one week before wounding. Wound breaking strength in animals that were simultaneously wounded and received chemotherapy was similar to controls. Both adriamycin and dihydroxyanthracenedione have a deleterious effect on one parameter of wound healing--wound breaking strength--when administered one week before wounding.

摘要

术前辅助化疗在晚期头颈癌中的应用频率越来越高；然而，化疗对伤口愈合的影响尚未完全阐明。为了评估术前化疗的效果，给实验动物使用化疗药物，造成伤口，然后测定随后的伤口抗张强度。大鼠在受伤前一周或受伤同时接受单剂量静脉注射杀肿瘤药物（阿霉素或二羟基蒽二酮）。在受伤后1周和2周测量接受治疗动物和未接受化疗的对照动物的伤口抗张强度。所有伤口，无论是否接受治疗，在受伤后2周时都比1周时更强。在受伤前一周给予化疗时，两个时间点的伤口抗张强度均降低。同时受伤并接受化疗的动物的伤口抗张强度与对照组相似。当在受伤前一周给药时，阿霉素和二羟基蒽二酮对伤口愈合的一个参数——伤口抗张强度——都有有害影响。