Scappaticci S, Forabosco A, Borroni G, Orecchia G, Fraccaro M
Biologia Generale e Genetica Medica, Università di Pavia, Italia.
Ann Genet. 1990;33(1):5-8.
Multiple numerical and structural chromosome abnormalities were found in cultured lymphocytes of four patients with Werner's syndrome. The proportion of metaphases with structural and/or numerical aberrations varied from 30 to 44% and several of them were clonal. These results confirm definitively that Werner's syndrome is a chromosome rearrangement syndrome and that these non-constitutional chromosome changes are not exclusive of cultured fibroblasts but present also in lymphocytes.
