Melaragno M I, Pagni D, Smith M A
Disciplina de Genética, Escola Paulista de Medicina, São Paulo, Brazil.
Mech Ageing Dev. 1995 Mar 1;78(2):117-22. doi: 10.1016/0047-6374(94)01530-y.
Lymphocyte cultures from five patients with Werner's syndrome (WS) and five healthy controls revealed significantly slower proliferation kinetics in four out of five patients. Higher frequencies of chromosome aberration and aneuploidy were also present with evidence of variegated translocation mosaicism in one of the patients. The study revealed no differences in sister chromatid exchange frequencies.
对五名沃纳综合征（WS）患者和五名健康对照者的淋巴细胞培养显示，五名患者中有四名的增殖动力学明显较慢。还出现了更高频率的染色体畸变和非整倍体，其中一名患者有斑驳易位嵌合体的证据。该研究未发现姐妹染色单体交换频率存在差异。
