Department of Endocrinology, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang, Hebei 050000, China.
Int J Endocrinol. 2013;2013:216107. doi: 10.1155/2013/216107. Epub 2013 Apr 17.
Objectives. Growth hormone deficiency patients exhibited reduced bone mineral density compared with healthy controls, but previous researches demonstrated uncertainty about the effect of growth hormone replacement therapy on bone in growth hormone deficient adults. The aim of this study was to determine whether the growth hormone replacement therapy could elevate bone mineral density in growth hormone deficient adults. Methods. In this meta-analysis, searches of Medline, Embase, and The Cochrane Library were undertaken to identify studies in humans of the association between growth hormone treatment and bone mineral density in growth hormone deficient adults. Random effects model was used for this meta-analysis. Results. A total of 20 studies (including one outlier study) with 936 subjects were included in our research. We detected significant overall association of growth hormone treatment with increased bone mineral density of spine, femoral neck, and total body, but some results of subgroup analyses were not consistent with the overall analyses. Conclusions. Our meta-analysis suggested that growth hormone replacement therapy could have beneficial influence on bone mineral density in growth hormone deficient adults, but, in some subject populations, the influence was not evident.
生长激素缺乏症患者的骨密度低于健康对照组，但以往的研究对生长激素缺乏症成年人的生长激素替代治疗对骨骼的影响存在不确定性。本研究旨在确定生长激素替代治疗是否可以提高生长激素缺乏症成年人的骨密度。
在这项荟萃分析中，检索了 Medline、Embase 和 The Cochrane Library，以确定生长激素治疗与生长激素缺乏症成年人骨密度之间关联的人类研究。本研究采用随机效应模型进行荟萃分析。
共有 20 项研究（包括一项异常值研究），涉及 936 名受试者，纳入本研究。我们发现生长激素治疗与脊柱、股骨颈和全身骨密度的总体增加有显著相关性，但一些亚组分析的结果与总体分析不一致。
我们的荟萃分析表明，生长激素替代治疗可能对生长激素缺乏症成年人的骨密度有有益影响，但在某些人群中，这种影响并不明显。
