Department of Endocrinology, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang, 050000, Hebei Province, China.
Endocrine. 2012 Dec;42(3):546-54. doi: 10.1007/s12020-012-9684-1. Epub 2012 May 1.
Previous researches demonstrate uncertainty about the effect of metabolic syndrome (MS) on bone. We performed a meta-analysis to investigate the association of MS with bone mineral density (BMD) of spine and femoral neck (FN). In this meta-analysis, searches of Medline, Embase, Cochrane Library, Chinese biological medical database and China national knowledge infrastructure were undertaken to identify studies in humans of the association between MS and BMD. Random effects model was used for this meta-analysis. The results of our research were reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A total of 11 studies (including an outlier study) with 13,122 subjects were included in our research. We detected a significant overall association of MS with increased BMD of spine (weighted mean difference, WMD = 0.027, 95 % confidence interval, CI [0.011, 0.042]) and no significant overall association of MS with BMD of FN (WMD = 0.008, CI [-0.011, 0.026]). Subgroup analyses indicated significant association between MS and increased BMD of spine in subjects whose BMD was measured by dual-energy X-ray absorptiometry (DXA) scanner manufactured by Hologic Inc., subjects diagnosed by International Diabetes Federation criteria and subjects diagnosed by National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III) criteria. And significant association between MS and increased BMD of FN in Caucasian subjects, subjects whose BMD was measured by DXA scanner manufactured by Hologic Inc. and subjects diagnosed by NCEP-ATP III criteria was also found. Our meta-analysis suggests that MS has no clear influence on BMD, or its influence maybe beneficial.
先前的研究表明，代谢综合征（MS）对骨骼的影响存在不确定性。我们进行了一项荟萃分析，以研究 MS 与脊柱和股骨颈（FN）骨密度（BMD）之间的关系。在这项荟萃分析中，我们检索了 Medline、Embase、Cochrane 图书馆、中国生物医学文献数据库和中国国家知识基础设施，以确定人类 MS 与 BMD 之间关联的研究。本荟萃分析采用随机效应模型。我们的研究结果按照系统评价和荟萃分析的首选报告项目进行报告。共有 11 项研究（包括一项异常值研究），涉及 13122 名受试者，纳入了我们的研究。我们发现 MS 与脊柱 BMD 增加之间存在显著的总体关联（加权均数差，WMD = 0.027，95%置信区间，CI [0.011, 0.042]），而 MS 与 FN BMD 之间不存在显著的总体关联（WMD = 0.008，CI [-0.011, 0.026]）。亚组分析表明，在使用 Hologic Inc. 生产的双能 X 射线吸收仪（DXA）测量 BMD 的受试者、国际糖尿病联合会（IDF）标准诊断的受试者和国家胆固醇教育计划成人治疗专家组 III（NCEP-ATP III）标准诊断的受试者中，MS 与脊柱 BMD 增加之间存在显著关联。在白种人受试者、使用 Hologic Inc. 生产的 DXA 测量 BMD 的受试者和 NCEP-ATP III 标准诊断的受试者中，MS 与 FN BMD 增加之间也存在显著关联。我们的荟萃分析表明，MS 对 BMD 没有明显影响，或者其影响可能是有益的。
