Samman S, Khosla P, Carroll K K
Department of Biochemistry, University of Western Ontario, London, Canada.
Ann Nutr Metab. 1990;34(2):98-103. doi: 10.1159/000177575.
The aim of this study was to investigate the underlying causes of elevated levels of intermediate density lipoprotein (IDL) in rabbits fed casein compared to soy protein in a cholesterol-free, semipurified diet. Kinetic studies were carried out in which homologous, radiolabelled IDL was injected into casein- and soy protein-fed animals after a period of 7 months on diet. Total plasma cholesterol and IDL cholesterol and protein were significantly higher in animals fed casein compared to those fed soy protein. The fractional catabolic rate of IDL-apolipoprotein B was significantly lower in casein-fed animals but the difference in mean values for the production rate did not reach statistical significance. The effect of feeding casein on IDL can be attributed to its reduced efficiency of removal from the plasma.
本研究的目的是调查在无胆固醇的半纯化饮食中，与大豆蛋白喂养的兔子相比，酪蛋白喂养的兔子中中间密度脂蛋白（IDL）水平升高的潜在原因。进行了动力学研究，在饮食7个月后，将同源的放射性标记IDL注射到酪蛋白和大豆蛋白喂养的动物体内。与大豆蛋白喂养的动物相比，酪蛋白喂养的动物血浆总胆固醇、IDL胆固醇和蛋白质显著更高。酪蛋白喂养的动物中IDL-载脂蛋白B的分数分解代谢率显著更低，但平均生成率的差异未达到统计学显著性。喂养酪蛋白对IDL的影响可归因于其从血浆中清除的效率降低。
