Munck-Wikland E, Kuylenstierna R, Lindholm J, Wahren B
Department of Oto-Rhino-Laryngology, Karolinska Hospital, Stockholm, Sweden.
Anticancer Res. 1990 May-Jun;10(3):703-8.
The serum levels of Carcinoembryonic antigen, CA 19-9 and CA 50 were assessed in 60 patients with squamous cell carcinoma of the esophagus during the course of the disease. In 53 patients, the effect of preoperative or final treatment on tumor marker levels could be analysed, and the change in tumor marker levels discriminated significantly the patients who showed tumor mass/symptom regress from the patients who displayed progress or undecided change. Progress later in the course of the disease was reflected by a statistically significant increase in all three tumor marker assays, and in 8/18 (44%) patients the tumor marker increase was seen prior to other signs of tumor progression. The appearance of distant metastases was associated (11/12) with increase in CEA levels.
在60例食管鳞状细胞癌患者病程中对癌胚抗原、CA 19-9和CA 50的血清水平进行了评估。在53例患者中，可以分析术前或最终治疗对肿瘤标志物水平的影响，肿瘤标志物水平的变化显著区分了肿瘤肿块/症状消退的患者与病情进展或变化未明的患者。疾病后期的进展表现为所有三种肿瘤标志物检测结果在统计学上显著升高，并且在18例患者中有8例（44%）在出现其他肿瘤进展迹象之前就出现了肿瘤标志物升高。远处转移的出现与癌胚抗原水平升高相关（11/12）。
