Ikeda K, Terashima M, Ishida K, Okamoto K, Suzuki S, Murakami K, Ohtsu T, Suzuki K, Niitsu Y, Obonai H
1st Dept. of Surgery, Iwate Medical University.
Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 1):677-82.
The levels of squamous cell carcinoma-related antigen (SCC) in sera of 71 patients with esophageal squamous cell carcinoma, 7 patients with benign esophageal diseases, 11 gastric cancer patients and 15 normal volunteers were studied in order to evaluate its clinical significance as a tumor marker. In the patients with esophageal carcinoma, immunosuppressive acidic protein (IAP) and carcinoembryonic antigen (CEA) were also measured simultaneously. In the normal volunteers, patients with benign esophageal diseases and gastric cancer patients, the SCC levels were negative except for only one patient. However, in patients with carcinoma of the esophagus 37 out of 71 were positive, the positivity rate being 52.1%. Comparison among SCC, IAP and CEA showed that the positivity rates for SCC and IAP increased with progression of the disease. In contrast, CEA levels did not correspond to clinical stage except in several patients with non-resectable and recurrent disease. With regard to the changes in serum levels of SCC, IAP and CEA before and after surgery and radio-chemotherapy. SCC was the most sensitive marker of the three, and responded well to the effects of therapy. SCC was thus considered to be a useful marker for monitoring esophageal cancer patients.
为评估鳞状细胞癌相关抗原（SCC）作为肿瘤标志物的临床意义，对71例食管鳞状细胞癌患者、7例食管良性疾病患者、11例胃癌患者及15名正常志愿者血清中的SCC水平进行了研究。对食管癌患者同时测定了免疫抑制酸性蛋白（IAP）和癌胚抗原（CEA）。在正常志愿者、食管良性疾病患者及胃癌患者中，除1例患者外，SCC水平均为阴性。然而，71例食管癌患者中有37例呈阳性，阳性率为52.1%。SCC、IAP和CEA之间的比较显示，SCC和IAP的阳性率随疾病进展而升高。相比之下，CEA水平除在几例不可切除和复发疾病患者中外，与临床分期不相符。关于手术及放化疗前后SCC、IAP和CEA血清水平的变化，SCC是三者中最敏感的标志物，对治疗效果反应良好。因此，SCC被认为是监测食管癌患者的有用标志物。
