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The first organoantimony(III) compounds possessing antitumor properties: diphenylantimony(III) derivatives of dithiophosphorus ligands.

作者信息

Silvestru C, Socaciu C, Bara A, Haiduc I

机构信息

Chemistry Department, University of Cluj-Napoca, Romania.

出版信息

Anticancer Res. 1990 May-Jun;10(3):803-4.

PMID:2369094
Abstract

Two organoantimony (III) derivatives, i.e., diphenylantimony diphenyl-dithiophosphinate, Ph2SbS2PPh2, and diphenylantimony diizopropyldithiophosphate, Ph2SbS2P(OPri)2, were shown to exhibit antitumor properties. Both compounds produced strong tumor inhibition effects in mice bearing Ehrlich ascites tumor. Moreover, the dithiophosphate (15 mg/kg, i.p., in days 1, 3 and 5) produced a cure rate of 30%.

摘要

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