Department of Urology, Urologic Institute of PLA, Southwestern Hospital, Third Military Medical University, Chongqing, China.
PLoS One. 2013 May 14;8(5):e63227. doi: 10.1371/journal.pone.0063227. Print 2013.
Transurethral resection of the prostate (TURP) has a high failure rate in patients with small volume benign prostate hyperplasia (BPH) with bladder outlet obstruction (BOO). We describe and report the results of an alternative surgical method, selective transurethral resection of the prostate (STURP) in combination with transurethral incision of the bladder neck (TUIBN).
Patients were randomized to receive TURP or STRUP+TUIBN in combination with TUIBN. Maximum urinary flow rate (Qmax), voided volume, and post voiding residual volume (PVR) were assessed at baseline and at 1, 3, and 6 months after surgery. Efficacy of treatment was assessed by lower urinary tract symptoms and IPSS.
Sixty three patients received STRUP+TUIBN and 61 received TURP. Surgical time, amount of prostate tissue resected, and blood loss was the same in both groups (all, p>0.05). The mean duration of follow-up was 9.02 and 8.53 months in patients receiving TURP and STRUP+TUIBN, respectively. At 6 months postoperatively, IPSS was 4.26±1.22 and 4.18±1.47 in patients receiving TURP and STRUP+TUIBN, respectively (p>0.05), and the Qmax in patients receiving STRUP+TUIBN was markedly higher than in those receiving TURP (28.28±6.46 mL/s vs. 21.59±7.14 mL/s; p<0.05). Bladder neck contracture and urinary tract infections were observed in 3 and 5 patients receiving TURP, respectively, and none in STURP.
STRUP+TUIBN may offer a more effective and safer alternative to TURP for small volume BPH patients.
经尿道前列腺切除术(TURP)治疗小体积良性前列腺增生(BPH)合并膀胱出口梗阻(BOO)的患者,其失败率较高。我们描述并报告了一种替代手术方法,即选择性经尿道前列腺切除术(STURP)联合经尿道膀胱颈切开术(TUIBN)的结果。
患者随机分为 TURP 组或 STRUP+TUIBN 联合 TUIBN 组。分别于基线、术后 1、3 和 6 个月评估最大尿流率(Qmax)、排尿量和残余尿量(PVR)。采用下尿路症状和 IPSS 评估治疗效果。
63 例患者接受了 STRUP+TUIBN 治疗,61 例患者接受了 TURP 治疗。两组的手术时间、切除的前列腺组织量和出血量均相同(均,p>0.05)。接受 TURP 和 STRUP+TUIBN 治疗的患者平均随访时间分别为 9.02 和 8.53 个月。术后 6 个月,接受 TURP 和 STRUP+TUIBN 治疗的患者的 IPSS 分别为 4.26±1.22 和 4.18±1.47(p>0.05),而接受 STRUP+TUIBN 治疗的患者的 Qmax 明显高于接受 TURP 治疗的患者(28.28±6.46 vs. 21.59±7.14 mL/s;p<0.05)。接受 TURP 治疗的患者中有 3 例出现膀胱颈挛缩,5 例出现尿路感染,而接受 STRUP+TUIBN 治疗的患者中均未出现。
对于小体积 BPH 患者,STRUP+TUIBN 可能是 TURP 的一种更有效、更安全的替代方法。