Robinson P H, Stephenson J S
Department of Psychological Medicine, King's College Hospital School of Medicine and Dentistry, U.K.
Appetite. 1990 Jun;14(3):193-201. doi: 10.1016/0195-6663(90)90087-o.
In rats allowed to eat for only 2 h per day, gastric emptying of three different meals [poached egg white, glucose (0.5 kcal/ml) and physiological saline, each labelled with 60 MBq of technetium-99m tin colloid visualized using a gamma camera] was markedly slowed 8 h after the last meal. Mean body weight in rats on the restricted feeding schedule was 80% of the weight of free-feeding controls. Gastric emptying curves for all three meals in controls were best described using loge transformed counts. Other models used were linear and square root. For each of the three meals, the percentage remaining in the stomach at 120 min was estimated using linear regression of gastric contents, transformed if necessary to yield the best curve against time. At 120 min, % gastric contents (mean +/- SEM) were 19.5 +/- 5.6 (egg), 15.5 +/- 6.27 (glucose) and 27.1 +/- 7.48 (saline) in control rats. After 4 months restriction, the corresponding figures were 75.2 +/- 4.04, 81.5 +/- 4.75 and 70.3 +/- 5.83. After 3 months of free feeding, emptying rates of the three meals were not significantly different from control values. We conclude that dietary restriction causes profound changes in gastric emptying by unknown mechanisms which may be operating in patients with anorexia nervosa.
在每天仅允许进食2小时的大鼠中，最后一餐8小时后，三种不同食物（水煮蛋白、葡萄糖（0.5千卡/毫升）和生理盐水，每种均用60兆贝可的锝-99m锡胶体标记，通过γ相机显像）的胃排空明显减慢。限制进食时间表的大鼠平均体重为自由进食对照组体重的80%。对照组中所有三种食物的胃排空曲线用对数转换计数描述最佳。使用的其他模型是线性和平方根模型。对于三种食物中的每一种，在120分钟时胃内剩余的百分比通过胃内容物的线性回归估计，必要时进行转换以产生最佳的时间曲线。在120分钟时，对照大鼠的胃内容物百分比（平均值±标准误）分别为19.5±5.6（蛋白）、15.5±6.27（葡萄糖）和27.1±7.48（盐水）。限制4个月后，相应数字分别为75.2±4.04、81.5±4.75和70.3±5.83。自由进食3个月后，三种食物的排空率与对照值无显著差异。我们得出结论，饮食限制通过未知机制导致胃排空发生深刻变化，这些机制可能在神经性厌食症患者中起作用。
