McCallum R W, Grill B B, Lange R, Planky M, Glass E E, Greenfeld D G
Dig Dis Sci. 1985 Aug;30(8):713-22. doi: 10.1007/BF01320484.
Upper gastrointestinal symptoms may be prominent in anorexia nervosa. This study is an investigation of the gastric emptying of solid and liquid meal components in 16 female patients (mean age 20.0 years, range 14-40 years) who met accepted psychiatric diagnostic criteria for anorexia nervosa. The results were compared with those of gastric emptying studies in 10 normal females of ideal body weight (mean age 25.4 years, range 20-35), 13 normal persons (12 males), and six patients (mean age 12 years, range 9-14 years) with weight loss (less than 90 percent ideal body weight) secondary to Crohn's disease with no psychiatric symptoms. A dual-isotope technique using chicken liver intracellularly labeled with technetium-99m (99mTc) bound to sulfur colloid as the solid-phase marker, and indium-111 (111In) -labeled water as the liquid-phase marker was used. Gastric emptying was monitored for 2 hr by gamma camera. In 13 of the 16 anorexia nervosa patients (80%), gastric emptying of solids was slower than the range in the two groups of normal subjects, and mean gastric emptying was significantly slower (P less than 0.05) than in the weight-loss patients. Liquid emptying (water) in anorexia nervosa was normal and similar to the control groups studied. In 11 of the anorexia nervosa patients with delayed gastric emptying, intramuscular metoclopramide, 10 mg, significantly (P less than 0.05) accelerated the mean gastric emptying from 60 through 120 min after the meal. We conclude that in anorexia nervosa patients who are symptomatic and seeking medical care: gastric emptying of solids is significantly delayed when compared with female subjects of similar age and normal body weight and with patients of less than 90% ideal body weight but without psychiatric disorder; these data are consistent with an antral motility disturbance, either primary or secondary; and metoclopramide, a gastric prokinetic agent, accelerates (delayed) gastric emptying.
上消化道症状在神经性厌食症中可能较为突出。本研究对16例符合公认的神经性厌食症精神科诊断标准的女性患者（平均年龄20.0岁，范围14 - 40岁）固体和液体餐成分的胃排空情况进行了调查。将结果与10名理想体重的正常女性（平均年龄25.4岁，范围20 - 35岁）、13名正常人（12名男性）以及6例继发于克罗恩病且无精神症状的体重减轻患者（平均年龄12岁，范围9 - 14岁，体重低于理想体重的90%）的胃排空研究结果进行了比较。采用双同位素技术，使用与硫胶体结合的锝-99m（99mTc）细胞内标记的鸡肝作为固相标记物，铟-111（111In）标记的水作为液相标记物。用γ相机监测胃排空2小时。16例神经性厌食症患者中有13例（80%）固体胃排空比两组正常受试者的范围慢，平均胃排空明显比体重减轻患者慢（P < 0.05）。神经性厌食症患者的液体排空（水）正常，与所研究的对照组相似。在11例胃排空延迟的神经性厌食症患者中，肌肉注射10毫克甲氧氯普胺显著（P < 0.05）加速了餐后60至120分钟的平均胃排空。我们得出结论，对于有症状并寻求医疗护理的神经性厌食症患者：与年龄相仿、体重正常的女性以及体重低于理想体重90%但无精神障碍的患者相比，固体胃排空明显延迟；这些数据与原发性或继发性胃窦动力障碍一致；胃促动力剂甲氧氯普胺可加速（延迟的）胃排空。
